The home team is a favorite to win this tournament, let alone this match. There is quality in the squad - Juventus's Arturo Vidal and Arsenal's Alexis Sanchez perhaps foremost - and they can expect to have a strong crowd behind them (46,000 was the reported attendance for Chile's opening game against Ecuador).
Mexico would be the underdog even if it hadn't sent a B-team to Copa America - and the recently announced squad for Gold Cup confirmed that the group in Chile is indeed the second tier El Tri's options. Further complication has arrived in the form of injury to Rafa Marquez. The veteran center back will miss the rest of the group stage, which could effectively mean he misses the rest of Mexico's participation in this tournament.
Under the circumstances - an already under-strength team now missing a key defensive component - a draw would be a very creditable result for El Tri against Chile.