The U.S. won Group A and faces Group B runner-up Ecuador. The winner of this match will face the winner of Argentina v. Venezuela, in the semifinals.
The USMNT defeated Ecuador 1-0 in a pre-Copa America friendly in May.
The U.S. will be without suspended rightback DeAndre Yedlin. Ecuador is expected to be at full strength.
Players from both teams are likely to be fatigued, as the USMNT will be playing its fourth game in eleven days and this will be La Tricolor's fourth match in ten days.
This game is expected to be close and if the U.S. needs a late goal, look for Jurgen Klinsmann to bring on Darlington Nagbe. Nagbe scored the 90th game winner for the U.S. in its recent 1-0 victory against Ecuador.
The USMNT has never lost at CenturyLink and will look to extend this streak.