The U.S. will likely be in for a tough match, as the team's all-time away record against Guatemala is 1-0-5.
The status of star U.S. midfielder Fabian Johnson is in question, as he was injured recently while playing for Borussia Mönchengladbach. Jozy Altidore's fitness is also a concern as he came off of the bench to play thirteen minutes, his first minutes of the MLS season, last weekend for Toronto FC.
Guatemala is expected to be at full strength and will be led by attacking stars Marco Pappa of the Colorado Rapids and former MLS player Carlos Ruiz.
The two sides will meet again on Tuesday, in Columbus, to play another World Qualifying Match.